periductal stromal tumor breast pathology outlinesperiductal stromal tumor breast pathology outlines

The histologic characteristics to be considered are many and often heterogeneous in the same lesion which makes interpretation in needle biopsy material difficult. WebPeriductal stromal condensation may be seen; Frankly sarcomatous stroma may be seen in malignant phyllodes tumor Heterologous differentiation may occur in malignant phyllodes tumor Liposarcoma; Osteosarcoma; Chondrosarcoma; Rhabdomyosarcoma; Grading determined by presence or absence of atypical stromal features; Kristin C Jensen MD PSS is a tumor of intermediate behavior; it may evolve into a phyllode tumor as well as a specific soft-tissue sarcoma. Periductal stromal tumor: a rare lesion with low-grade sarcomatous behavior. Feel free to get in touch with us and send a message. PDST is distinguished from phyllodes tumor by its lack of leaf-like architecture; however, it is still unclear whether PDST is a separate entity or a certain spectrum of phyllodes tumor. J Med Case Reports 5, 249 (2011). Grossly, the tumor in the lumpectomy specimen measured 8.5cm 6.5cm 5cm in size with a gray-pink section, solid texture, and lobulated borders. 1969, 98: 384-387. PMC All authors read and approved the final manuscript. Chen CM, Chen CJ, Chang CL, Shyu JS, Hsieh HF, Harn HJ: CD34, CD117, and actin expression in phyllodes tumor of the breast. Manuscript preparation: ND, LK. Further inquiries can be directed to the corresponding authors. The tumor shows infiltrative borders. The tumor is largely circumscribed with focally infiltrative borders. Google Scholar. In this case, infiltrative growth, rich in interstitial cells, obvious atypia, active mitosis (>10/10 HPF or 5/mm2), and pathological mitosis indicated malignancy. International journal of surgical pathology. 10.1097/00000478-199407000-00008. WHO Classification of Tumors of the Breast. ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. As a biphasic tumor, PDST shows both benign ductal epithelium and non-phyllodes sarcomatous stroma. 2006; [PubMed PMID: 16889904], Niezabitowski A,Lackowska B,Rys J,Kruczak A,Kowalska T,Mitus J,Reinfuss M,Markiewicz D, Prognostic evaluation of proliferative activity and DNA content in the phyllodes tumor of the breast: immunohistochemical and flow cytometric study of 118 cases. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).

Journal of clinical pathology. Compared with FFDM alone, DBT plus FFDM demonstrated higher cancer detection rate (18). Figure1 Timeline of the relevant data of this case. As far as we know, only sporadic cases were reported ( 1 9 ). Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. Breast Imaging-Reporting and Data System (BI-RADS) 3. 2012 Oct; [PubMed PMID: 22981939], Nielsen VT,Andreasen C, Phyllodes tumour of the male breast. DBT, which involves multiple projections, is a promising technique for breast cancer screening and diagnosis. It is unclear whether this tumor belongs to the spectrum of Currently, resection with adequate margins is generally considered sufficient, and axillary lymphadenectomy is not needed. WebPeriductal stromal sarcoma (PSS) is a type of rare malignant fibroepithelial tumor. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( WebThe tumor microenvironment regulates tissue development and homeostasis, and its dysregulation contributes to neoplastic progression. Which of the following features is diagnostic of malignant phyllodes tumor? Pathol Int. PubMed Comparative genomic hybridization studies showed recurrent chromosome imbalances, including +1q, 6q, 13q, 9p, 10p, and +5p. Before doi:10.1136/jclinpath-2012-201078, 14. Multiple banded hyperechogenic septa were noted (Figure2).

Am J Surg Pathol (2003) 27:3438. The patient underwent extended mastectomy of the right breast. Pre-operative diagnosis is difficult because it reveals similar symptoms with other benign and malignant tumors with absence of specific Puisez votre inspiration dans nos propositions d'excursionet petit petit, dessinez lavtre. Tl: +84 913 025 122 (Whatsapp) As a biphasic tumor, PDST shows both benign ductal epithelium and non-phyllodes sarcomatous stroma. Scattered stromal mitotic figures are noted. For this case, a 3-month interval follow-up plan was recommended. WebCriteria for periductal stromal hyperplasia included 1) nodular, bland stroma growing as cuffs around normal or altered ducts, 2) no to minimal atypia, and 3) at most 02 stromal mitotic figures per 10 high power fields. Terms and Conditions, Trauma, pregnancy, increased estrogen activity, and lactation are occasionally implicated as A 48-year-old woman was admitted with an 8-year history of right breast mass. [1], Multiple immunohistochemistry markers have undergone a study in an attempt to improve the classification of PT and predict their outcomes. Fibroadenomas typically present as unilateral firm non-tender masses. They were mainly distinguished by pathological characteristics. The mass had been steady at the size of a jujube until it grew rapidly during the few months before admission. R C, G M, GM V, S L. Low Grade Periductal Stromal Sarcoma With Marked Sclero-Elastosis.

No adjuvant treatment was given. However, we cannot answer medical or research questions or give advice. As a biphasic tumor, PDST shows both benign ductal epithelium and non-phyllodes sarcomatous stroma. These tumors are usually benign, but they can come back and cause the breast to look abnormal if not totally removed. As a biphasic tumor, PDST shows both benign ductal epithelium and non-phyllodes sarcomatous stroma. The resection margins were negative (range, 2mm to 13mm).

Article 1985, 201: 527-532. Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. As far as we know, no classic imaging features have been reported due to the rarity of PDST. Periductal stromal sarcoma in a child: a case report, https://creativecommons.org/licenses/by/2.0. Indian J Pathol Microbiol (2008) 51:2524. Written informed consent was obtained from the patient's next of kin for publication of this case report and any accompanying images. doi:10.1016/s0002-9610(03)00269-1, 18. WebAbstract Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. [16][17], PAX3 and SIX1 expression by immunohistochemistry and gene expression analysis have recently been identified in borderline and malignant phyllodes tumors and correlate with a poor clinical outcome.[18]. Explorer le Vietnam dans toute sa grandeur ou juste se relaxer en dcompressant sur des plages paradisiaques. Circuit Incontournables du Nord Vietnam vous permet la dcouverte de beaux paysageset de diverses ethnies. [23] Large tumors require a mastectomy. Surgery with negative margins is commonly accepted as the first choice of treatment. Most phyllodes tumors behave benignly, with local recurrences occurring in a small proportion of cases. Periductal Stromal Tumors and Phyllodes Tumors Represent a Spectrum of Fibroepithelial Lesions: What Is in a Name?

Pre-operative diagnosis is difficult because it reveals similar symptoms with other benign and malignant tumors with absence of specific Studies demonstrate that p53, Ki67, CD117, EGFR, p16, and VEGF (being the lowest in benign phyllodes tumors and the highest in malignant phyllodes tumors) are associated with histologic grades of phyllodes tumors, but none has been proven to be clinically useful. Guarantor of integrity of the entire case study: LK, ZJ, HX.

PSS is a recently introduced diagnostic entity and there are few reports about radiological features of this tumor. Please enable it to take advantage of the complete set of features! Periductal Stromal Sarcoma in a Child: A Case Report. E:info@vietnamoriginal.com, Suite B11.25, River Gate Residence, 151-155 Ben Van Don St, Dist 4 Very rarely, the tumor may metastasize. Copyright 2021 Ding, Jiang, Liu, Zheng, Zhu, Wang, Yang, Kong, Xue and Jin. https://creativecommons.org/licenses/by/2.0

Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Online ahead of print. In this care report, we describe the first such case in a child reported in the literature. Identify the etiology of phyllodes breast tumors. volume5, Articlenumber:249 (2011) Its therapeutic management is based on wide surgery with free margins. Microscopic (optional): Sections show a stromal proliferation featuring areas of leaf-like pattern and stromal expansion with moderate cellularity and stromal atypia. These tumors are usually benign, but they can come back and cause the breast to look abnormal if not totally removed. World Health Organization: World Health Organisation Classification of Tumours 2003, Pathology and Genetics Tumours of the Breast and Female Genital Organs. The tumor measures ____ in maximal dimension and is clear from (specify if < 1 cm ____) / involves the resection margins. Immunohistochemistry showed the tumor cells to be CD34-positive (Figure 4) and S-100-, ER- and PR-negative. WebPeriductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. A retrospective search of our Pathology database from 2000 to 2021 identified 6 PST, all evaluated according to the Armed Forces Institute of Pathology (AFIP) criteria.

Masbah, O., Lalya, I., Mellas, N. et al. WebPeriductal Stromal Tumor of the Breast: One Institution's Review of 6 Tumors Over a 22 Year Period With Immunohistochemical Analysis Int J Surg Pathol. Periductal stromal tumor (PST) of the breast is a rare fibroepithelial neoplasm with controversial pathogenesis. A copy of the written consent is available for review by the Editor-in-Chief of this journal. The size may range from 1 to 45 cm and may occupy the entire breast. 1. Digital Breast Tomosynthesis: Concepts and Clinical Practice. Researchers have postulated that stromal induction of phyllodes tumors can occur due to growth factors produced by the breast epithelium. Contributed by Joshua J.X. The masses measured in total 7.8cm 9.1cm 7.4cm in size, integrated, with irregular shape and multiple lobulations. The surgical pathology confirmed a PDST. [1], There have been proposals for several grading systems, but the use of the three-tiered system, including benign, borderline, and malignant phyllodes tumor, is preferred because this approach leads to greater certainty at the ends of the spectrum of these fibroepithelial lesions. Zhang Y,Kleer CG, Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates. In this case, the suspicious feature of multiple internal septa and irregular boundaries were more clearly depicted in DBT than FFDM (Figures35), providing more evidence for a precise diagnosis. Phyllodes tumors constitute a group of rare epithelial lesions of the breast which mainly develops at around 40-50 years. Federal government websites often end in .gov or .mil. PDST is distinguished The patient underwent extended mastectomy of the right breast. The large masses comprising nearly the entire right breast, with lobulated irregular margin, the banded median-high echogenic septum was seen inside the mass. Lexpertise acquise avec lexprience du temps, la passion du voyage et des rencontres humaines toujours intacte nous permettent de vous proposer le meilleur des escapades et excursions au Vietnam et en Asie du Sud- Est. The Journal of pathology. WebCriteria for periductal stromal hyperplasia included 1) nodular, bland stroma growing as cuffs around normal or altered ducts, 2) no to minimal atypia, and 3) at most 02 stromal mitotic figures per 10 high power fields. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2005 Dec; [PubMed PMID: 16258510], Tse GM,Lui PC,Vong JS,Lau KM,Putti TC,Karim R,Scolyer RA,Lee CS,Yu AM,Ng DC,Tse AK,Tan PH, Increased epidermal growth factor receptor (EGFR) expression in malignant mammary phyllodes tumors. The largest lesion was located 2cm from the areola area, which measured 7.1cm 9.1cm 5.6cm, and internal mass echogenicity was heterogeneous with abundant internal vascularity. Pathol Int (2009) 59:58891. [1] Phyllodes tumor presents a morphologic continuum from benign to malignant. Methods. Invasive ductal carcinoma (IDC) can be displayed as a large mass or multiple fused masses and enlarge rapidly. 2013; [PubMed PMID: 23577269], Jing P,Wei B,Yang X, Phyllodes tumor of the breast with nipple discharge: A case report. Correspondence to

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WebThe Korean Journal of Pathology 2014; 48: 442-444 Periductal Stromal Tumor of Breast 443 CD117. The epithelial component corresponded to ducts with borders, sometimes double and sometimes with mild to moderate hyperplasia without atypia. Ann Clin Lab Sci (2018) 48:7705. Its therapeutic management is based on wide surgery with free margins. Very rarely, the tumor may metastasize, most commonly in the cases of malignant grade tumors. Its therapeutic management is based on wide surgery with free margins. Front. 1968, 22: 22-28. Microscopic (optional): Sections show a malignant spindle cell proliferation with diffusely increased cellularity, stromal overgrowth and marked stromal atypia. Local recurrences generally develop within 2 to 3 years.[28]. 2014 May; [PubMed PMID: 24438019], Gullett NP,Rizzo M,Johnstone PA, National surgical patterns of care for primary surgery and axillary staging of phyllodes tumors. Authors Longmei Zhao 1 , Miglena K Komforti 1 , Andrea Dawson 1 , J Jordi Rowe 1 Affiliation Epithelial structure surrounded by a stroma with moderate atypical cells showing mitosis. Wabik A, Van Bockstal M, Berlire M, Galant C. Periductal Stromal Tumors and Phyllodes Tumors Represent a Spectrum of Fibroepithelial Lesions: What Is in a Name?

Written informed consent was obtained from the individual for the publication of any potentially identifiable images or data included in this article. 10.1097/00000658-198504000-00020. Lyon, France: IARC Press (2012). 2009, 59: 588-591. Ulceration and nipple retraction are uncommon. 2021 Feb;29(1):97-101. doi: 10.1177/1066896920929086. Previously classified with cystosarcoma with adipose metaplasia [2, 47], PSS was recently recognized as a separate entity and was given its own place in the World Health Organization classification system at the consensus conference in Lyon in 2002 [1]. Periductal stromal sarcoma in a child is a very rare disease which has the same indolent behavior as it does in adults. 2018 Aug; [PubMed PMID: 30029048], Goto W,Kashiwagi S,Takada K,Asano Y,Morisaki T,Noda S,Takashima T,Onoda N,Hirakawa K,Ohira M, [A Case of a Malignant Phyllodes Tumor That Was Difficult to Distinguish from Stromal Sarcoma]. 2. Some regard tumors with predominant periductal stromal expansion (i.e., periductal stromal tumor) as a distinct subtype of phyllodes tumor Graded into benign, borderline and malignant histologic grades *Defined as absence of epithelial elements containing stroma only in 1 low power field J Breast J (2020) 26:13758. A Study of 32 Patients With Reappraisal of Classification and Therapy. 2008 Jul 1; [PubMed PMID: 18234448], Ruiz-Flores L,Ebuoma LO,Benveniste MF,Nagi C,OrtizPerez T,Benveniste AP, Case Report: Metastatic Phyllodes Tumor. Breast cancer research and treatment. Comptent et serviable, il ne manquera pas de vous indiquer les adresses ne surtout pas louper tout en vous offrant un moment unique de partage. Tl: +84 913 025 122 (Whatsapp) It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. Cookies policy. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases. It is unclear whether this tumor belongs to the spectrum of Figure4 (AD) Craniocaudal position of digital breast tomosynthesis. DBT was recommended than FFDM alone as the added value in recognizing suspicious features. Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. PDST is distinguished from ph Bloody nipple discharge caused by spontaneous infarction of the tumor has been described. [7], Unlike breast carcinoma, phyllodes tumors start outside of the lobules, and ducts, in the breasts connective tissue, called the stroma, including the ligaments and fatty tissue surrounding the lobules, ducts, lymph, and blood vessels in the breast. info@meds.or.ke Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma made of spindle cells and lacking phyllodes architecture. Bethesda, MD 20894, Web Policies This immunoprofile together with histomorphology results confirmed the diagnosis of PDST.

The treatment results for 340 patients from a single cancer centre. T2-weighted images usually show a lobulated mass with hyperintense fluid in slit-like spaces and sometimes hyperintensity in the surrounding tissues. Despite the higher incidence of local recurrence secondary to breast-conserving surgery, studies have shown no differences between breast-conserving surgery versus mastectomyregardingmetastasis-free survival or overall survival. The symptoms most commonly found are similar to other benign and malignant breast tumors and have no radiological specificity [2]. Chen C-M, Chen CJ, Chang CL, Shyu JS, Hsieh HF, Harn HJ. Would you like email updates of new search results? [1], This variety comprises 60% to 75% of all phyllodes tumors. Microscopic (optional): Sections show a stromal proliferation in a leaf-like pattern capped by benign ductal epithelium and intact intervening myoepithelial cell layer. Upon clinical examination, we found, in the upper outer quadrant of the right breast, a small mass measuring approximately 2cm in size, round in shape, with no signs of inflammation and not associated with axillary lymph nodes. WebPeriductal stromal condensation may be seen Frankly sarcomatous stroma may be seen in malignant phyllodes tumor Heterologous differentiation may occur in malignant phyllodes tumor Liposarcoma Osteosarcoma Chondrosarcoma Rhabdomyosarcoma Grading determined by presence or absence of atypical stromal features Kristin C Jensen MD These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. The breast lesion was classified as Breast Imaging-Reporting and Data System (BI-RADS) 3 by FFDM and BI-RADS 4A based on DBT and US. [1] Phyllodes tumors have an inherent recurrence and/or metastatic potential, which varies based on histologic grade. The histopathological features of IDC vary considerably from case to case and can even vary within the same case. Periductal stromal sarcoma is an extremely rare malignant fibroepithelial tumor of the breast which is characterized by its biphasic histology with benign ductal elements and a sarcomatous stroma made of spindle cells and lacking phyllodes architecture. It is characterized by proliferation of atypical spindle cells surrounding benign mammary The lungs (66%), the bones (28%), and the brain (9%) are the most common sites of spread. Oberman HA, Nosanchuk JS, Finger JE: Periductal stromal tumors of breast with adipose metaplasia.